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A: Yes if you get symptoms like very high restlessness (trembling), constant anxiety, racing heart, difficulty sleeping at night, or feeling wired, those might be signs your dose is too high

There is very little information in literature about the brown or black melanotic lesions of the oral mucosas that are not a manifestation of racial pigmentation and are not associated with other syndromes

FEMS Microbiol Rev 41:430449

Progressive neurodegeneration after experimental brain trauma: Association with chronic microglial activation

Another set of intestines and livers were homogenized in the same volume of PBS containing 20 mM NEM and then allowed to stand for 10 min at 25 C