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A 2025 matched-cohort study found men who started testosterone therapy had significantly higher rates of tendon tears and repairs at one and two years compared to controls, a pattern the authors attributed to testosterone's effect on tendon biomechanics outpacing the tissue's regenerative capacity Sherman et al

Crucially, it achieves this without altering systemic hormone levels or modifying metabolic pathways, keeping background variable noise completely absent from your laboratory datasets

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