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doi: 10.1016/j.cmet.2006.01.004 58

Ongoing Laboratory Monitoring During Treatment During the maintenance phase, laboratory tests may be repeated every six to twelve months depending on the patients medication regimen, overall health, and clinical progression

In the preclinical literature it is described across six complementary axes: angiogenesis via VEGFR2/eNOS/NO, regulation of FAK-paxillin signalling, protection of the endothelium and the gastric-intestinal mucosa, modulation of the brain-gut axis with the NO pathway, tendon maturation with fibroblast proliferation, and cytoprotection as a common denominator

This ultimately enhances the activity of melanogenic enzymes, including tyrosinase, which is involved in the production of melanin