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157 Although it is generally assumed that AT 2 receptors oppose the responses mediated by AT 1 receptors, and therefore may attenuate the pressor effects of Ang II, a possible role of AT 2 receptors in the regulation of renal hemodynamics and sodium homeostasis remains to be unclear

to assess the extent of the problem

In: Shils M, Shike M, Ross A, Caballero B, RJ C, eds

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In many cases, what is interpreted as angiogenic activity may instead reflect other forms of vascular remodelingsuch as BBB disruption, pericyte loss, or basement membrane alterationsrather than true neovascularization