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By promoting telomere elongation, Epitalon may help maintain cell viability and function for a longer period, thereby slowing down the aging process

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The other two adducts, 2,3-dihydro-2-(N-formyl-2,3,6-triamino-4-oxopyrimidine-N-yl)-3-hydroxy AFB 1 and 8,9-dihydro-8-(2-amino-6-formamide-4-oxo-3,4-dihydropyrimid-5-yl formamido)-9-hydroxy AFB 1 (AFB 1 -FAPY and AFB 1 III respectively) are not spontaneously but appear to be removed catalytically by DNA repair enzymes

In addition, BBB dysfunction has been implicated in aging and neurodegenerative diseases, both of which are associated with an increased risk of depression

Furthermore, amino acid residues with hydrophobic side chains in the 1-position of the Ang IV analogues, e.g., a norleucine residue (cf