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(NEJM 2007, n=412) documented a reduction of -15.2% in visceral adipose tissue, +81% in IGF-1, -50 mg/dL in triglycerides and -0.31 in the cholesterol/HDL ratio at 26 weeks (2 mg SC/day vs placebo)
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Of note, dual receptor agonists have significantly advanced incretin-based therapy by concurrently engaging glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors within a single peptide molecule
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