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Pipeline of obesity pharmacotherapies GLP-1 receptor agonists GLP-1 RA increase satiety, reduce food intake and delay gastric emptying whilst they also stimulate insulin release and inhibit glucagon secretion in a glucose-dependent manner (Fig

However, their variable BBB permeability and non-selective action often result in side effects such as neuropsychiatric issues and impulse control disorders 55,56,57

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