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Karges gratefully acknowledges the financial support provided by the Liebig fellowship from the Chemical Industry Fund of the German Chemical Industry Association, the Life Sciences Bridge Award from the Aventis Foundation, and the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2024 a prize awarded by the Paul Ehrlich Foundation, Germany

For these reasons, PregS more closely resembles the characteristics of classical neurotransmitters, such as acetylcholine, in which the parent molecule bears a full positive charge and is active only at an extracellularly directed recognition site while the immediate breakdown products (choline + acetic acid) are inactive

doi:10.1016/j.cmet.2016.06.021 41

Yamaguchi H, Kato H, Hata Y, et al