Similarly, in HD, one of the many explanations that have been put forth refers back to mitochondria, proposing that medium spiny neurons, known for having very high energy demands, are particularly vulnerable to mitochondrial malfunction and respiration suppression caused by mutant Huntingtin [46]
[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Zulli A., Smith R.M., Kubatka P., Novak J., Uehara Y., Loftus H., Qaradakhi T., Pohanka M., Kobyliak N., Zagatina A
2014;42:D802809
They naturally occur in the body and play a role in many biological functions, like signalling hormones, regulating metabolism, or managing inflammation
Arnr ESJ, Sarioglu H, Lottspeich F, Holmgren A, Bck A (1999) High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the sel A, sel B and sel C genes