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The mutual outcome of these two effects is the upregulation of hepatic BA formation and emission of conjugated BAs into the blood circulation, which distally anchors the FXR in the bone marrow, resulting in the loss of osteoblast function, negatively impacting BMD, bone volume fraction, and fracture resistance (115)
GLP-1 SGLT2 CBT-OB GLP-1 GLP-1 GLP-1 GLP-1 11 0.251mg 1124 11GLP-1GLP-1GIP21mg5mg 424 GLP-13mg7mg14mg 301345kg SGLT-2 SGLT-2 SGLT2SGLT2SGLT2SGLT2 L-25mg50mg2 SGLT233kg5% 1 0.25mg1140.5mg1141.0mg3 2mg353,400 28 F . 0.25mg1140.5mg1148 117,800 28 T T . 0.25mg1140.5mg1148 117,800 CBT-OB GLP-1 5100 CBT-OBCognitive Behavioral Therapy for Obesity 1870 2 BMI17 2 2024 GLP-1 GLP-1FDA 30 3 3mg 10 3mg 100 1,850 17,500 7mg 10 7mg 100 4,250 40,000 14mg 10 14mg 100 6,400 60,000 1,100 1,100 2,200 30 25 25mg 10 25mg 100 1,900 18,000 50mg 10 50mg 100 2,700 25,500 1,100 1,100 2,200 1 0.25mg 2mg 1 2mg 12 16,000 30,000 1,100 1,100 1,100 2,200 4mg2 7.5mg 4 2.5mg 2.5mg 12 6,200 3,100/ 2.5mg 612 33,600 2,800/ 5mg 12 11,300 5,650/ 5mg 612 63,600 5,300/ 7.5mg 12 15,800 7,900/ 7.5mg 612 90,000 7,500/ 1,100 1,100 2,200 30 3 3mg 10 3mg 100 1,850 17,500 7mg 10 7mg 100 4,250 40,000 14mg 10 14mg 100 6,400 60,000 1,100 1,100 2,200 30 25 25mg 10 25mg 100 1,900 18,000 50mg 10 50mg 100 2,700 25,500 1,100 1,100 2,200 1 0.25mg 2mg 1 2mg 12 16,000 30,000 1,100 1,100 1,100 2,200 4mg2 7.5mg 4 2.5mg 2.5mg 12 6,200 3,100/ 2.5mg 612 33,600 2,800/ 5mg 12 11,300 5,650/ 5mg 612 63,600 5,300/ 7.5mg 12 15,800 7,900/ 7.5mg 612 90,000 7,500/ 1,100 1,100 2,200
(20:21): And we now have a really large phase three study ongoing, but of course, it's a hypothesis, right
This work was supported by the Helmholtz Association, the German Centre for Lung Research (DZL), the Ministry of Health of the Czech republic (grant number NT 13433-4/2012, IGA MZR), and the Max-Planck Society for the Advancement of Science
