Geetika Arora, an endocrinologist at Northwell's Phelps Hospital, puts it simply: "The trade-off comes down to convenience versus maximum weight loss." In a Lilly-funded trial published by The Lancet, patients on 12 to 36 milligrams of orforglipron lost an average of 15 to 20 pounds, compared with 8 to 11 pounds for those on 7 to 14 milligrams of Rybelsus
Overall, further research in a prospective fashion is required to investigate the underlying mechanism of NAION, assess the likelihood of recovery after GLP-1 discontinuation, and provide a comprehensive guideline for clinicians and patients to follow
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Table 3 summarizes the findings of the main analyses for safety outcomes
Enjalbert B, Smith DA, Cornell MJ, Alam I, Nicholls S, et al