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A recent 2024 network meta-analysis confirmed that an oral dose of 600 mg/day of ALA effectively lowers the Total Symptom Score (TSS) and the Neuropathy Impairment Score (NIS) compared to a placebo

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The components are put into an IV bottle and infused intravenously over 20 minutes

Pathophysiological studies indicate that the mechanisms underlying delayed healing of diabetic wounds are multifaceted, with ROS burst and oxidative stress cascades triggered by the high-glucose microenvironment, inducing RCD, which may represent a core cause of non-healing wounds