Since CGRP participates in goblet cell hyperplasia and muc5AC induction in other disease models [39], it is possible that it is also involved in CF exacerbations, in which increased muc5AC has been noted [135]
Researchers considering extended protocols should be aware that this safety gap exists and should monitor for unexpected effects in tissues where NNMT has normal physiological functions
This was a recommendation both in the James Lind Alliance Priority Setting Partnership which PAS initiated and funded and in the NICE Guideline on B12 Deficiency which PAS initiated
Higher doses are associated with potential side effects such as severe abdominal pain, stomach problems, nausea, vomiting, diarrhea, and constipation
Consider your experience level Beginners (never used peptides): Start with safest, most forgiving peptides BPC-157, collagen peptides, basic GH peptides Avoid aggressive or complex protocols Intermediate (used 1-3 peptides): Can try more potent options Stack 2-3 peptides safely Understand dosing and cycles Advanced (extensive peptide experience): Can use powerful peptides (IGF-1, aggressive GH protocols) Complex stacks Self-monitor and adjust See our getting started with peptides guide and common peptide mistakes beginners make