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Therefore, as an expected extension of the theoretical framework concerning adverse effects [1], the extensive model complexities and the involvement of a multitude of biological targets [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168] should, axiomatically, be associated with the emergence of adverse outcomes

10.1038/sj.emboj.7601633 53 GiannaccareG.PellegriniM.SenniC.BernabeiF.ScorciaV.CiceroA

Steiner HL 3rd, et al

The etiology of vitamin D deficiency can be attributed to a multitude of factors, including aging, inadequate engagement in outdoor activities, excessive use of sunscreen, inadequate vitamin D supplementation, obesity, high latitudes, and diet [14]

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