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5 Japanese research from 1994 into the effects of B12 therapy in patients with multiple sclerosis shows that a daily tablet with 60 mg methylcobalamin during six months is non-toxic

Because of the hypothesised abnormalities in oxidative stress and suggested links between initial inflammation, glutamate excitotoxicity and neuronal dysfunction/loss [25], our additional interest was in, GSH, glutamate and glutamine, and total choline as biomarkers of these processes

Associations between vitamin C intake and serum uric acid in US adults: Findings from National Health and Nutrition Examination Survey 20112016

These findings suggest that gastrointestinal distension serves as a physiological stimulus for GLP-1 secretion and that this mechanism may be effective in preventing and ameliorating hyperphagic obesity

PMID 9636157