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also showed muscle atrophy was more pronounced after ablation of muscle IGF-1 production than when hepatic IGF-1 production was suppressed (Bikle et al., 2000

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We observed co-localization of a phosphorylated NPM1 (T199), a protein that shuttles between the nucleolus and the nucleus 28,29 , and -H2AX, a histone protein that binds to DNA damage sites 30 (Fig