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However, Ellenbroek and colleagues have indicated that long-term KD interventions do not lead to a reduction in blood glucose levels

The dependence of both tolerance and the recovery from desensitization on GRK, - arrestin2, and dynamin would predict that the explanation for MOR tolerance may be an enhanced rate of endocytosis after chronic morphine

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As illustrated in Supplementary Figure 2B, also the coupling efficiency deteriorates in the presence of oxidative stress