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2.5.7.3 Duvakitug Duvakitug (TEV-48574) is a fully human IgG1 monoclonal antibody that targets TL1A-DR3 signaling to reduce inflammation and fibrosis in IBD patients, studied in the Phase 2b RELIEVE UCCD trial (NCT05499130) which randomized 290 adults with moderate to severe UC or CD to receive subcutaneous duvakitug (450mg or 900mg every 2 weeks after loading dose) or placebo for 14 weeks across 164 global sites

That moves you out of the two-compound stack and into a three-compound protocol

Rybelsus must be taken on an empty stomach with water only, and you must wait at least 30 minutes before taking any food, drink, or other oral medications including magnesium supplements

J Cell Physiol 1999

The 503B large-scale pathway is being formally restricted