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40:1479-1485 [PMC free article: PMC5652593] [PubMed: 28827404] 220

The observed gender differences in nicotine craving reductions indicate that female participants were significantly more likely to report reduced nicotine cravings compared with males, a finding that remained significant after adjustment for potential confounders (adjusted odds ratio [aOR] 0.27 for males vs females, 95% CI 0.120.61

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These modifications protect against degradation by dipeptidyl peptidase-4 (DPP-4), an enzyme that would otherwise chew through the molecule in minutes