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Pharmacological HDAC inhibitors, such as sodium butyrate or CI-994, reverse these transcriptional changes and rescue ethanol-induced social withdrawal and despair behaviors
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5.2 Neurotransmitter and neuroendocrine regulation Periodontitis-related oral dysbiosis can disrupt the gut microbiota via multiple pathways, contributing to depression through neurotransmitter and neuroendocrine mechanisms
By restoring more youthful GH pulse patterns through physiological secretagogue stimulation rather than exogenous GH administration, the combination is studied as a model for investigating age-associated metabolic, body-composition, and tissue-quality changes without bypassing native regulatory feedback loops
doi:10.3109/03602532.2011.561353
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