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We used SAIGE 46 to obtain single-variant summary statistics, adjusting linear regressions for age, sex, and the first ten genetic principal components

Here, they are rapidly oxidized, recognized by scavenger receptors, and then phagocytosed by macrophages and macrophage-like VSMCs, which induces foam cell formation and plaque progression 65

This provides a pathway for a potential effect of GLP1-RA beyond glucose regulation