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A fourth reason for your b12 shots not working is that you have something else going on

Growth Factors 9 , 5771 (1993)

Instead of one drug, one disease, we should think of designing drugs that impact multiple diseases.

Figure 2 5 Excessive androgens/AR impairs mitochondrial quality control and function in females Different from the androgen deficiency-related negative impact on mitochondria in males, excessive androgens and/or overactivation of AR play detrimental roles in mitochondrial quality control and functions in females