The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]
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It has not been linked to any notable side effects or toxicity, whether applied topically or via subcutaneous injection
Understanding the peptides potential role in gut health requires a broader look at how the gastrointestinal system influences metabolic function
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