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Berberine has known potential for uterotonic effects and can cross the placenta, with evidence of fetal harm in some animal studies

Beyond receptor genes, variants in FTO (fat mass obesity) and MC4R (melanocortin pathway) influence baseline metabolic rate and appetite signalingfactors that tirzepatide modulates directly

Moreover, challenges such as weak mechanical stability under physiological conditions, sterilization-related degradation, and high production costs hinder industrial scalability [487,488,489]

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Over-diluting creates larger volumes that must be stored longer, increasing degradation exposure