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Snyder added that weight-loss medications should be considered as just one tool in a comprehensive plan

Common side effects during the adjustment period (typically the first 24 weeks): Mild nausea usually less intense than when first starting a GLP-1 medication Changes in appetite (some patients notice less appetite suppression early on at the starting 0.25 mg dose) Mild stomach discomfort, bloating, or constipation Injection site reactions Side effects that are less likely during the switch (compared to first-time GLP-1 use), but still possible: Significant vomiting less common given prior GLP-1 exposure, but possible Hypoglycemia particularly relevant for type 2 diabetes patients on insulin or sulfonylureas

The usual out-of-pocket price for semaglutide in the US is between $800 and $1,500 every month

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Many people will experience a weight loss plateau on semaglutide around the 12-to-15-month mark