Curr Neurovasc Res 18(1):134149 Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA (2018) OLT1177, a -sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
In this sense, some Turkish populations have been traditionally consuming high amounts of hot chili pepper (capsaicin) in food and it has been observed a high incidence of epilepsy in these areas (unpublished data)
It plays a central role in the recognition, conjugation, and neutralization of potentially harmful endogenous and exogenous compounds before they can induce cellular damage
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