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A comparison of iPSC-derived BECs from control and patients with Huntington's disease (HD), differentiated using Lippman's method, revealed HD-related defects in angiogenesis and BBB maturation related to WNT pathway dysregulation (Lim et al., Validation of in vitro Human BBB Models and Specific Adaptation for Studies on BBB Neuropathogenicity How should BBB models be validated
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Notably, the proposed binding mode is compatible with the simultaneous binding of the substrate L-Leu- p NA, in agreement with the uncompetitive IRAP inhibition determined for a representative compound
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