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The STEP 1 trial of semaglutide (the active ingredient in Ozempic and Wegovy) - published in The New England Journal of Medicine , 2021 - also reported secondary data showing modest lean mass reductions alongside the significant total weight loss the trial is known for

P values calculated by GraphPad were rounded to three decimal places

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Many patients and providers consider these medications together when managing type 2 diabetes or prediabetes, but understanding how they differ is essential for tailored treatment