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Additionally, there was variation in the quality of included studies as the risk of bias, methodological rigor, and data integrity were not well tracked or standardized across the available articles

However, enzyme supplements may cause their own gastrointestinal side effects that can overlap with GLP-1-related symptoms, and some formulations containing bromelain or papain may interact with anticoagulants

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CYP2R1 expression was not seen in FL83B mouse hepatocytes) and 1--hydroxylase (CYP27B1), along with the increased expression of 24-hydroxylase (CYP24A1), was observed in GSH-deficient hepatocytes