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However, the specific downstream effectors of PI3K/AKT/mTOR that mediate autophagy-ferroptosis crosstalk, along with potential subtype-specific differences, require further definition

3.4 Microglia in demyelinating conditions Microglial cells are extensively involved in the MS pathogenesis, apparently displaying a dual role of fostering inflammation, triggering synaptopathy and neurodegeneration, and sustaining the remyelination processes

Think of it as your bodys natural cleaning and protection system

NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development

Egger M, Davey Smith G, Schneider M, Minder C