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There is only the case of the nuclear transcription factor c-Jun that, due to an unusual redox potential, could react with GSSG at relatively high ratio of GSH/GSSG = 13 (Klatt et al., 1999)

It has been proposed that increased urinary carnitine may be a result of impaired renal tubule function contributing to decrease carnitine reabsorption (Kpka et al., 2016) as alcohol abuse can impair renal reabsorption (Labib et al., 1989)

10.1172/JCI106747 J Clin Invest

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Oral supplements must pass through the digestive system, where absorption can be as low as 20-30%