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The lower dose helps reduce the risk of side effects while your body gets used to the medication

It appears to accomplish this, in part, by modulating the nitric oxide (NO) system

While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation, and abdominal pain) are the most frequently reported side effects, fatigue and asthenia (weakness) are recognized drug-associated effects

[DOI] [PubMed] [Google Scholar] 3.Iraola-Guzmn S, Estivill X, Rabionet R

[5] Table 3: Semax nasal spray dosage general reported ranges * These ranges are informational only and reflect published research or clinical practice reports