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This low efficacy may be due to the poor solubility of hydrophobic CPPs 61

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Some endogenous neuropeptides do cross via saturable transport systems, and there is speculation that DSIP may do so, but this has not been rigorously demonstrated for exogenously administered peripheral DSIP in humans

The research primarily investigated the potential action of the peptide on dermal procollagen synthesis, keratinocyte proliferation, differentiation, and cutaneous inflammation

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