Among these regulatory systems, three have emerged as particularly compelling therapeutic targets due to their pivotal involvement in both physiological and pathological contexts: The excitatory amino acid transporter 2 (EAAT2, also known as GLT-1 in rodents), aquaporin-4 (AQP4), and purinergic receptors, particularly the P2X 7 and P2Y 1 subtypes
As with females, CR and DL-fed 3xTg and NTg males had comparable reductions in calorie intake relative to AL-fed males (Fig
For one subject, the spectrum obtained at the second post-dose time point was of insufficient quality, and was omitted from analysis
DSIP has also been evaluated in laboratory settings examining cortisol dynamics and central neurotransmitter balance
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