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showed that oxidative stress-mediated aortic cell ferroptosis predisposed to thoracic aortic aneurysm (TAA) formation in humans and animal models with selenoprotein deficiency

Studies with complete reporting and rigorous design were rated as "High," while others with some limitations or missing methodological details were rated as "Medium" or "Low." To evaluate the reliability and scientific rigor of the evidence presented in this review, we conducted a methodological quality assessment of the primary clinical trials included

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One documented case described a 43-year-old woman who experienced exercise-induced anaphylaxis where shilajit acted as a cofactor