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337,338 Structural mitochondrial abnormalities such as disrupted cristae are widely documented in FTLD-TDP, AD, mixed AD/PD, and HD, linking altered mitochondrial architecture to impaired ATP production, calcium dysregulation, synaptic dysfunction, and eventual neuronal death

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As a result, it acts close to its source, oxidizing nearby biomolecules, while H 2 O 2 can freely diffuse across cell membranes and oxidize molecules farther away, such as pathogen membrane lipids

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So CT-388s effect could grow in future readouts for the Phase II trial

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The marketing around lipotropic injections oversells the mechanism

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Figures 5A,D,J)

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