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Data availability The data analyzed during this study are included in this manuscript

The concern surrounding Gilberts syndrome and paracetamol is based on the putative theory that a reduction in the glucuronidation of paracetamol leaves a greater fraction of the drug available to be oxidised, potentially causing toxicity

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Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms