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In high-glucosechallenged retinal pigment epithelial cells, PCs activate the p53/mTOR autophagy pathway, lowering apoptosis-related factors (e.g., Bax, Caspase-3, LC3-II/LC3-I, and phosphorylated p53) and elevating the levels of survival proteins (Bcl-2, p62, and phosphorylated mTOR) (Li et al., 2022)
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Endocrinology 152(8):31033112 Klausen MK, Jensen ME, Mller M, Le Dous N, Jensen A-M , Zeeman VA, Johannsen C-F, Lee A, Thomsen GK, Macoveanu J (2022) Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial
These combined effects indicate stronger engagement of elasticity-related pathways in controlled experimental settings
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