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With MTHFR, what started as mutations are now a common part of the human gene pool, just like blue eyes, lactose tolerance, and many others

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However, patients with irritable bowel syndrome or IBD are better off with a low-FODMAP diet, as it can exacerbate disease symptoms due to gas production and stretching of the intestinal lumen [8, 130,131,132]

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Unfunded Mandates Reform Act (UMRA) Section 202 of the Unfunded Mandates Reform Act of 1995 (UMRA) also requires that agencies assess anticipated costs and benefits before issuing any rule whose mandates require spending in any 1 year of $100 million in 1995 dollars, updated annually for inflation