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A randomized controlled trial reported the benefit of delta inulin as an immune adjuvant in patients with bee-venom allergy, and found that delta inulin increased the levels of specific IgG 4 significantly during the early induction phase (169)

doi: 10.1016/S0006-2952(03)00343-5

175 CRTCs have also been suggested to be involved in ACTH-induced transcription of StAR (Steroidogenic Acute Regulatory) protein, where ACTH mediates the recruitment of CRTC2 and CRTC3 to the StAR promoter leading to increased levels of Star heteronuclear RNA, 176 indicating that these co-activators modulate context-specific activation of diverse genes

ASBT-mediated endocytosis occurs when bile acids specifically bind to ASBT, inducing a transformational change in the occluded state of ASBT and the formation of ASBT vesicles for endocytosis [32, 44, 45]

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