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Intestinal hormones, neurotransmitters, and interstitial cells of Cajal (ICCs) play essential roles in regulating intestinal movement, which may be influenced by dietary fiber (12)

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Interestingly, an adjacent population of GABAergic neurons is activated by fasting but inhibited by the proopiomelanocortin (POMC) cleavage product alpha-melanocyte stimulating hormone (alpha-MSH), and their activation increases food intake [108]

Since semaglutide is a drug that impacts your appetite and blood sugar levels, it may be indirectly related to hydration and glucose levels