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Note that GLP-1 receptor agonists should not be used in combination with DPP-4 inhibitors (e.g., sitagliptin, linagliptin) as per NICE guidance

Improved glycaemic control may reduce vascular complications that contribute to cognitive decline, whilst potential neuroprotective effects could directly influence disease progression

Interestingly, Fab 3F52 blocked the BMS21-induced response with potency in the low nanomolar range, similar to the inhibition of native GLP-1

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Because the level of PAI-1 is correlated with atherosclerosis formation [41] and is markedly elevated in T2D patients with CVD compared with healthy or T2D patients without CVD [42], this result implies more fibrinolytic thereby less atherogenic processes