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The approval is based on new data from a post-approval clinical study which demonstrated that semaglutide (2.4 mg once weekly by subcutaneous injection, for up to five years) lowers the incidence of major adverse cardiovascular events (MACE) vs placebo

Advocates suggest it can help repair tissues, from the digestive system to muscles, tendons, and ligaments

Reduced desensitization risk: Alternating receptor pathways mitigates receptor fatigue or downregulation seen in monotherapy 1-5

Retatrutide will likely follow the same pattern this is a chronic medication, not a temporary intervention

PloS One (2014) 9:e92193