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Miller and Robert Miller (listed as joint first authors), and Dr

Saxenda (liraglutide) produces more modest results, typically 5-10% weight loss

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Researchers chose other diabetes drugs as the comparison, rather than people on nothing, since patients starting any of these drugs tend to look similar health-wise, then used statistics to smooth out remaining differences, like GLP-1 starters being younger and heavier on average

Orforglipron also demonstrated superiority over oral semaglutide (Rybelsus) in a head-to-head trial for blood sugar control and weight loss in type 2 diabetes, delivering better results with fewer food and water intake restrictions