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We next used membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) to cleave the ectodomain of the IR in BMECs to construct a model of cells lacking the ectodomain of IR 24

Statistical methods A linear mixed-effects model for repeated measures was used for the primary outcome, Glx/tNAA change from baseline

Future research designs should go beyond simple body composition assessments, taking muscle strength, physical performance, and quality of life as core clinical endpoints to clarify the long-term effects of GLP-1RAs on different subgroups

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