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Notice that its structure is like selenocysteine, but with a methyl group added (like the name suggests)

52 Acknowledging the limitations of the design while referencing the pivotal trial, the Pediatric Endocrine Society stated, [] the severe phenotype of untreated adults, the significant increase in (near-) adult height reported, the unanimous growth velocity acceleration compared to pre-treatment values in multiple short-term studies, and the lack of an alternative treatment make IGF-1 a strongly recommended treatment for growth failure in patients with primary insulin-like growth factor-1 deficiency []. 14 Health-Related Quality of Life As HRQoL was not reported in any of the studies included in the current review (it was investigated in the EU-IGFD Registry, but data were only available for 2 patients at baseline and some time point thereafter), the impact of mecasermin on HRQoL is unknown