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These potential applications are supported by small RCTs and mechanistic studies indicating ECM remodeling, antioxidant effects, and anti-inflammation [1, 2, 3, 5, 8]

Notice its the HPA axis as a whole which is implicatednot just the adrenals

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Although the concentrations are much lower than pharmacological supplement doses, dietary melatonin can be bioavailable and may contribute to circulating melatonin levels