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Mechanistically, reduced expression of peroxisome PGC-1 and mitochondrial TFAMkey regulators of mitochondrial biogenesis and oxidative phosphorylationcompromises hepatic energy production and adaptability (147)

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We dont know how the prices of novel GLP-1s will change, we dont know what new GLP-1s will be introduced, we dont know how many generics there will be, we dont know how many people will ultimately use them, we dont know how long people will stay on them, we dont know what Medicare drug price negotiations will do to the price, and we dont even know if reducing obesity impacts long-term health spending

and a speaker for Novartis, Sanofi and Amgen