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10.1038/nchembio.238

Finally, the corresponding alkyne-tagged -halothioamide probes were evaluated by pull-down chemoproteomics, confirming robust proteome-wide target engagement, excellent cysteine selectivity and labelling of a distinct protein subset compared to the conventional iodoacetamide probe

They have shown potential for regulating cell growth and inducing apoptosis in cancer cells, making them a promising target for cancer therapy [246]

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The transcription factor NF-E2-related factor 2 (NRF2), which binds the antioxidant response element (ARE) present in the promoter region of antioxidant enzymes (AOEs) plays a key role in the expression of AOEs 6