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[12] [13] Semaglutide works primarily by enhancing insulin secretion in response to elevated glucose levels, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

It binds to GLP-1 receptors found on: Pancreatic -cells Stimulates glucose-dependent insulin secretion Pancreatic -cells Suppresses glucagon release during hyperglycemia Hypothalamic satiety centers Reduces appetite and food intake Gastrointestinal tract Delays gastric emptying, enhancing satiety This multi-site activity leads to improved glycemic control, reduced body weight, and cardiovascular benefits

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